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๐—” ๐—ฑ๐—ฟ๐˜‚๐—ด’๐˜€ ๐—ฒ๐—ณ๐—ณ๐—ฒ๐—ฐ๐˜ ๐—ถ๐˜€ ๐—ฑ๐—ฒ๐—ฐ๐—ถ๐—ฑ๐—ฒ๐—ฑ ๐—ฏ๐˜† ๐—ฒ๐—น๐—ฒ๐—ฐ๐˜๐—ฟ๐—ผ๐—ป๐˜€. ๐— ๐—ผ๐˜€๐˜ ๐—ฐ๐—น๐—ฎ๐˜€๐˜€๐—ถ๐—ฐ๐—ฎ๐—น ๐˜๐—ผ๐—ผ๐—น๐˜€ ๐—ฐ๐—ฎ๐—ป’๐˜ ๐˜€๐—ฒ๐—ฒ ๐˜๐—ต๐—ฒ๐—บ ๐—ฐ๐—น๐—ฒ๐—ฎ๐—ฟ๐—น๐˜†.

Every drug on a pharmacy shelf took 10โ€“15 years and over $2.5B to develop โ€” much of it spent estimating how tightly a molecule binds its protein target. For most drugs, classical methods handle this well. But for metalloenzymes โ€”… Read More »๐—” ๐—ฑ๐—ฟ๐˜‚๐—ด’๐˜€ ๐—ฒ๐—ณ๐—ณ๐—ฒ๐—ฐ๐˜ ๐—ถ๐˜€ ๐—ฑ๐—ฒ๐—ฐ๐—ถ๐—ฑ๐—ฒ๐—ฑ ๐—ฏ๐˜† ๐—ฒ๐—น๐—ฒ๐—ฐ๐˜๐—ฟ๐—ผ๐—ป๐˜€. ๐— ๐—ผ๐˜€๐˜ ๐—ฐ๐—น๐—ฎ๐˜€๐˜€๐—ถ๐—ฐ๐—ฎ๐—น ๐˜๐—ผ๐—ผ๐—น๐˜€ ๐—ฐ๐—ฎ๐—ป’๐˜ ๐˜€๐—ฒ๐—ฒ ๐˜๐—ต๐—ฒ๐—บ ๐—ฐ๐—น๐—ฒ๐—ฎ๐—ฟ๐—น๐˜†.